abstract：AIM:Elderly donors are half of the grafts available in our center for liver transplantation. We retrospectively investigated their characteristics, outcomes, and variables related to graft failure. MATERIAL AND METHODS:From 1996 to 2003, 540 (46.4%) of 1163 donors were older than 60 years of age and 236 grafts (43.4%)...

journal_title：Transplantation proceedings

authors： Grazi GL,Ravaioli M,Zanello M,Ercolani G,Cescon M,Varotti G,Del Gaudio M,Vetrone G,Lauro A,Ramacciato G,Pinna AD

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND AIM:The clearance of plasma cytokines by means of albumin dialysis (MARS) has been demonstrated in various studies involving patients affected by either acute liver failure (ALF) or acute on chronic liver failure. The aim of the study was to measure the plasma levels of TNF-alpha, IL-6, and IL-1beta in p...

journal_title：Transplantation proceedings

authors： Di Campli C,Zocco MA,Gaspari R,Novi M,Candelli M,Santoliquido A,Flore R,Tondi P,Proietti R,Gasbarrini G,Pola P,Gasbarrini A

更新日期：2005-07-01 00:00:00

abstract：:In our initial experience of kidney transplantation, we performed an extravesical uretero-cystostomy (U-C), but in 1997 we shifted to a uretero-ureterostomy (U-U) with the aim of reducing early and late urological complications. A data base was constructed to compare the incidence, donor and recipient risk factors, tr...

journal_title：Transplantation proceedings

authors： Faenza A,Nardo B,Fuga G,Liviano-D'Arcangelo G,Grammatico F,Montalti R,Bertelli R,Beltempo P,Puviani L

更新日期：2005-07-01 00:00:00

abstract：:The aim of this study was to document, in hyperhomocysteinemic renal transplant recipients, the effect of vitamin supplementation on carotid intima-media thickness (cIMT). Fifty-six hyperhomocysteinemic stable renal transplant recipients were randomly assigned to either vitamin supplementation (group A) or placebo tre...

journal_title：Transplantation proceedings

authors： Marcucci R,Zanazzi M,Bertoni E,Rosati A,Fedi S,Lenti M,Prisco D,Castellani S,Abbate R,Salvadori M

更新日期：2005-07-01 00:00:00

abstract：INTRODUCTION:Mycophenolate mofetil (MMF) has greatly reduced the risk of acute rejection episodes (ARE) after renal transplantation, but dose reductions/withdrawals could jeopardize long-term results. METHODS:The MOST database of "de novo" patients treated with MMF at month 1 and functioning grafts at month 12 were di...

journal_title：Transplantation proceedings

authors： Salvadori M,Bock A,Chapman J,Dussol B,Fritsche L,Kliem V,Lebranchu Y,Oppenheimer F,Pohanka E,Tufveson G,Rosati A,Puig X,Corbetta G,MOST International Study Group.

更新日期：2005-07-01 00:00:00

abstract：:The lack of cadaver donors and the high requirements for organs cannot be met by present sources, leading to the need for xenoorgans or stem cell-derived tissues/organs. Actually, despite experimental suggestions, scientific and ethical doubts have been raised by both the scientific community and international organiz...

journal_title：Transplantation proceedings

authors： Frati P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Fas ligand gene transfer to induce peripheral allograft tolerance in animal models has shown controversial results. The immunosuppression effects mediated by engineered FasL depend on whether alloreactive T cells are selectively deleted. In the present study, we tested the feasibility of a strategy to induce...

journal_title：Transplantation proceedings

authors： Feng YG,Jin YZ,Zhang QY,Hao J,Wang GM,Xie SS

更新日期：2005-06-01 00:00:00

abstract：:Kidney transplantation in rats is a useful model for microsurgery, transplantation, and immunology studies. Our aim was to analyze various techniques of kidney transplantation in rats with emphasis on guidelines for the prevention and management of complications. Complications were categorized into general, vascular, ...

journal_title：Transplantation proceedings

authors： Pahlavan PS,Mehrabi A,Kashfi A,Soleimani M,Fani-Yazdi SH,Schemmer P,Gutt CN,Friess H,Weitz J,Kraus TW,Büchler MW,Schmidt J

更新日期：2005-06-01 00:00:00

abstract：:Veno-occlusive disease (VOD) of the liver occurs in 10% to 50% of patients after hematopoietic stem cell transplantation (HSCT), ranging from a mild reversible disease to a fulminant course with a mortality rate close to 100%. We retrospectively evaluated the clinical signs, diagnosis, prognosis, therapy, and outcome ...

journal_title：Transplantation proceedings

authors： Kalayoglu-Besisik S,Yenerel MN,Caliskan Y,Ozturk S,Besisik F,Sargin D

更新日期：2005-06-01 00:00:00

abstract：:Familial hypercholesterolemia (FH) is a dominant inherited disease of low-density lipoprotein (LDL) metabolism caused by mutations of LDL receptors mainly located in the liver. This metabolic disorder is responsible for severe cardiovascular disease, from coronary lesions to chronic heart failure (CHF). Liver transpla...

journal_title：Transplantation proceedings

authors： Alkofer BJ,Chiche L,Khayat A,Deshayes JP,Lepage A,Saloux E,Reznik Y

更新日期：2005-06-01 00:00:00

abstract：:The objective of the study was to assess the efficacy of antiviral therapy in patients with hepatitis C virus (HCV) recurrence after liver transplantation (OLT). We included 30 patients of mean age 56 years, who experienced HCV recurrence after OLT. Mean time from OLT to the beginning of therapy was 57 months (median:...

journal_title：Transplantation proceedings

authors： Moreno Planas JM,Rubio Gonzalez E,Boullosa Graña E,Garrido Botella A,Barrios Peinado C,Lucena Poza JL,Jiménez Garrido M,Sanchez Turrion V,Cuervas-Mons Martinez V

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Model for End-stage Liver Disease (MELD) scores at the time of listing on the transplant waiting list have been shown to accurately predict 3-month mortality in adults. There is no data assessing the accuracy of the MELD scores in predicting mortality of patients awaiting liver retransplantation. We sought...

journal_title：Transplantation proceedings

authors： Watt KD,Menke T,Lyden E,McCashland TM

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) is the main cause of renal transplant failure in the first decade posttransplant. The precise pathogenetic mechanism for CAN is not completely understood. A possible role of renin-angiotensin system for CAN has been suggested through clinical observations that angiotensin-...

journal_title：Transplantation proceedings

authors： Oka K,Moriyama T,Takahara S,Naruse M,Namba Y,Ichimaru N,Kyo M,Kokado Y,Okuyama A,Ito T,Imai E,Aozasa K

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Our goal was to analyze the morbidity of organic erectile dysfunction (ED) in kidney-transplant patients and to evaluate the efficacy and reliability of sildenafil citrate treatment. METHOD:Sixty-five ED patients with normal graft function for 3 to 12 months after kidney transplantation were involved in our ...

journal_title：Transplantation proceedings

authors： Zhang Y,Guan DL,Ou TW,Wang Y,Chen X,Xing NZ,Zhang XD,Yang Y

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:We sought to evaluate the efficacy of enteric-coated mycophenolate sodium (EC-MPS) and the gastrointestinal (GI) adverse events in de novo kidney transplant recipients. METHODS:This noncontrolled, retrospective review includes 22 de novo kidney transplant recipients. All patients received a standard cours...

journal_title：Transplantation proceedings

authors： Chang HR,Lin CC,Lian JD

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Laparoscopic surgery is rapidly emerging as the standard of care for a variety of urological conditions, even among patients who have undergone prior renal transplantation. We describe the technique of bilateral native nephrectomy and allograft nephrectomy by laparoscopy. CASE REPORT:A 32-year-old man wit...

journal_title：Transplantation proceedings

authors： Branco AW,Filho AJ,Kondo W,De George MA,Rangel M,De Carvalho RM,Noda RW

更新日期：2005-06-01 00:00:00

abstract：:Secondary brain insults predominantly due to hypotension are frequent among patients with fatal traumatic brain injury. We assessed the correlation between different systemic secondary brain insults and brain death in 404 patients admitted to our intensive care unit (ICU) after severe traumatic brain injury. We collat...

journal_title：Transplantation proceedings

authors： Sánchez-Olmedo JI,Flores-Cordero JM,Rincón-Ferrari MD,Pérez-Alé M,Muñoz-Sánchez MA,Domínguez-Roldán JM,Murillo-Cabezas F

更新日期：2005-06-01 00:00:00

abstract：:FK778, a derivative of the active leflunomide-metabolite, A77 1726, has been shown to be a powerful immunosuppressant in several transplantation models, particularly efficient in prevention of chronic allograft rejection. However, the cellular and molecular mechanisms underlying these effects of FK778 have not been in...

journal_title：Transplantation proceedings

authors： Zeyda M,Stuhlmeier KM,Kirsch B,Watschinger B,Hörl WH,Stulnig TM,Säemann MD

更新日期：2005-05-01 00:00:00

abstract：:Understanding specific tolerance mechanisms is a primary goal of transplantation science. We have previously shown that hosts treated with MHC class I protein have donor sequences in the alpha1-helix of the alpha1 domain on a background of self-epitopes, resulting in the development of donor-specific tolerance. Howeve...

journal_title：Transplantation proceedings

authors： Semiletova NV,Shen XD,Feldman DM,Busuttil RW,Kupiec-Weglinski JW,Ghobrial RM

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Human herpes virus (HHV8) is associated with Castleman's disease, primary effusion lymphoma, and the Kaposi's sarcoma (KS). PATIENTS AND METHODS:Among 3815 solid organ transplants performed at our center between 1977 and 2003, five patients (0.1%) were identified with KS. RESULTS:There were one cardiac, on...

journal_title：Transplantation proceedings

authors： Boeckle E,Boesmueller C,Wiesmayr S,Mark W,Rieger M,Tabarelli D,Graziadei I,Hoefer D,Antretter H,Stelzmueller I,Krugmann J,Zangerle R,Huemer H,Poelzl G,Margreiter R,Bonatti H

更新日期：2005-05-01 00:00:00

abstract：:In an open, prospective, multicenter study, stable renal graft recipients were converted to tacrolimus because of cyclosporine-related side effects. Seventy-five patients were switched primarily because of hyperlipidemia. After the switch to tacrolimus, mean total cholesterol was reduced by 15% at month 6. One hundred...

journal_title：Transplantation proceedings

authors： Pohanka E,Margreiter R,Sparacino V,Sperschneider H,European Switch to Tacrolimus Study Group.

更新日期：2005-05-01 00:00:00

abstract：:Sodium 4-phenylbutyrate (4-SPB), an aromatic derivative of butyric acid, was examined to elucidate its effect on islet engraftment in a syngeneic transplantation model using C57BL/6 mice. Diabetic mice that received subrenal implantation of 150 islets on day 0 and oral administration of twice daily 4-SPB (500 mg/kg bo...

journal_title：Transplantation proceedings

authors： Fu SH,Chen ST,Hsu BR

更新日期：2005-05-01 00:00:00

abstract：:Steroid-free immunosuppression regimens have been enjoying recent success in clinical transplantation. The use of antibodies required for such protocols can be an economic burden. We proposed to study their cost in our center. This retrospective study involved 147 consecutive patients subjected to 4 protocols of immun...

journal_title：Transplantation proceedings

authors： Nghiem DD,Carpenter BJ,Schlosser JD,Sureshkumar K,Vivas CA,Frowen SE,Marcus RJ

更新日期：2005-05-01 00:00:00

abstract：:The safety and efficacy of tacrolimus (Tac)-based immunosuppressive treatments were studied in 115 pediatric renal transplant recipients (mean follow-up period, approximately 20 months). The acute rejection rate was 22.7% 6 months after transplantation and the steroid-resistant acute rejection rate was 6.4%. The 5-yea...

journal_title：Transplantation proceedings

authors： Hasegawa A,Oshima S,Takahashi K,Uchida K,Ito K,Sonoda T

更新日期：2005-05-01 00:00:00

abstract：:We performed 24-hour monitoring of cyclosporine (NEO) and tacrolimus (TAC) blood concentrations, evaluating pharmacokinetic parameters and characterizing circadian variations. The monitoring was performed in 10 instances on nine patients administered NEO and 12 out of 11 patients administered TAC. All cases were admin...

journal_title：Transplantation proceedings

authors： Iwahori T,Takeuchi H,Matsuno N,Johjima Y,Konno O,Nakamura Y,Hama K,Uchiyama M,Ashizawa T,Okuyama K,Nagao T,Abudoshukur M,Hirano T,Oka K

更新日期：2005-05-01 00:00:00

abstract：:The prevalence of methicillin-resistant Staphylococus aureus (MRSA) has increased worldwide and MRSA has emerged as an important cause of sepsis in cirrhotic patients and liver transplant recipients. In this retrospective study, the prevalence of MRSA colonization and its influence on infections following orthotopic l...

journal_title：Transplantation proceedings

authors： Woeste G,Zapletal C,Wullstein C,Golling M,Bechstein WO

更新日期：2005-05-01 00:00:00

abstract：:The pathogenesis of ischemia-reperfusion injury is known to involve cytokines and particularly surface adhesion molecules, the expression of which initiates the attachment of inflammatory cells. Peroxisome proliferator-activated receptor (PPAR)-gamma is considered an important immunomodulatory factor as well as a fatt...

journal_title：Transplantation proceedings

authors： Matsuyama M,Yoshimura R,Hase T,Uchida J,Tsuchida K,Takemoto Y,Kawahito Y,Sano H,Nakatani T

更新日期：2005-05-01 00:00:00

abstract：:The cause of transplant failure may be difficult to define. However, organ retrieval before preservation and transplantation is an important factor. Organ manipulation during harvesting, which is inevitable with most techniques, leads to injury upon reperfusion including microcirculatory disturbances. Recently, laparo...

journal_title：Transplantation proceedings

authors： Schemmer P,Barro-Bejarano M,Mehrabi A,Gebhard MM,Kraus T,Büchler MW,Gutt CN

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:C2 (2-hour post-absorption levels) monitoring of cyclosporine (CsA) seems to reduce the rate of acute rejection episodes (ARE) without increasing nephrotoxicity during the first months after transplant. There are a few reports on the impact of adopting this strategy in patients with stable renal transplant...

journal_title：Transplantation proceedings

authors： Domínguez J,Fuenzalida D,Norambuena R,Pais E,Cortes Monroy G,Llanos R

更新日期：2005-04-01 00:00:00

abstract：:Heart transplantation is contraindicated in patients with acute irreversible pulmonary hypertension (PH), but new drugs are opening up therapeutic possibilities. Sildenafil citrate is a nonselective pulmonary vasodilator that is being used in our hospital to treat several patients with PH and which has allowed the inc...

journal_title：Transplantation proceedings

authors： Gómez-Moreno S,Lage E,Hernández A,Campos A,Cabezón S,Ordóñez A,Hinojosa R

更新日期：2005-04-01 00:00:00

abstract：:Hypertension is a frequent cardiovascular risk factor in liver transplant recipients. The usefulness of ambulatory blood pressure monitoring (ABPM) in these patients is unknown. This study was aimed at evaluating the circadian rhythms of blood pressure in liver allograft recipients. In 53 liver transplant patients blo...

journal_title：Transplantation proceedings

authors： Martínez-Rey C,Otero-Antón E,Tomé S,Rodríguez-Framil M,González-Quintela A,Calvo C,Hermida RC,Ayala D,Varo E

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:Liver transplantation is currently the best therapeutic option for small hepatocellular carcinoma (HC) in selected cirrhotic patients. The main aim of this study was to analyze the results of a recent series of liver transplant cirrhotic patients with small HC applying strict preoperative selection criteri...

journal_title：Transplantation proceedings

authors： Santoyo J,Suarez MA,Fernández-Aguilar JL,Jiménez M,Perez Daga JA,Sánchez-Perez B,Gonzalez Poveda I,Gonzalez-Sanchez A,Ramírez C,de la Fuente A

更新日期：2005-04-01 00:00:00

abstract：:In 3 renal transplant cohorts treated in Spain in 1990, 1994, and 1998 (total number, 3279), we studied the frequency of certain cardiovascular risk factors. Their effect on the cost of drugs was assessed from the data from 1 center; the mean cost of antihypertensive agents per patient-year was 349 euros, and of lipid...

journal_title：Transplantation proceedings

authors： Gentil MA,López M,González-Roncero F,Cantarell C,Marco J

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Renal transplants from elderly donors have a high incidence of delayed graft function, which can be increased by the initial use of calcineurin inhibitors. Our purpose was to assess the safety and efficacy of an immunosuppressive regimen using anti-IL-2R antibodies and MMF that allows delayed introduction of...

journal_title：Transplantation proceedings

authors： Osuna A,Gentil MA,Capdevila L,Cantarell C,Mazuecos A,Pereira P,Rodríguez-Algarra G,González-Molina M,Spanish Kidney Transplant of Elderly Donor Study Group.

更新日期：2005-04-01 00:00:00

abstract：:This paper reviews the formulation and evolution of the ethical component in one of the earliest clinical composite tissue allograft (CTA) programs, the hand transplantation program in Louisville, Kentucky, USA. The purpose was to derive lessons and define principles to give guidance for future programs and introducti...

journal_title：Transplantation proceedings

authors： Tobin GR,Breidenbach WC,Klapheke MM,Bentley FR,Pidwell DJ,Simmons PD

更新日期：2005-03-01 00:00:00

abstract：UNLABELLED:Pharmacokinetic (PK) parameters like C2h have improved efficacy of immunosuppressive therapy. However, drug interactions, toxicities, and individual differences to drug effects still remain challenging. Therefore, this study was designed to assess pharmacodynamic (PD) effects of the combination cyclosporin (...

journal_title：Transplantation proceedings

authors： Barten MJ,Rahmel A,Garbade J,Richter M,Bittner HB,Dhein S,Mohr FW,Gummert JF

更新日期：2005-03-01 00:00:00

abstract：:Pancreatic islet cell transplantation is a promising approach to restore the required mass of functional beta cells in diabetic patients as a means to achieve long-term normoglycemia. This therapy is, however, not yet widely used, in part because of the shortage of human islet cells. Gaining detailed knowledge of the ...

journal_title：Transplantation proceedings

authors： Hermann M,Pirkebner D,Draxl A,Margreiter R,Hengster P

更新日期：2005-03-01 00:00:00

abstract：:The modern surgical era of vascularized pancreas transplantation (PTX) began with the systemic-bladder drainage technique. According to International Pancreas Transplant Registry (IPTR) data, most PTX procedures are performed with systemic venous delivery of insulin and either bladder (systemic bladder) or enteric (sy...

journal_title：Transplantation proceedings

authors： Stratta RJ

更新日期：2005-03-01 00:00:00

abstract：AIMS:Since donor age of 45 years or more is considered a relative contraindication for pancreas transplantation (PTx), we herein report our experience with these donors. METHODS:Pancreases from donors aged 45 years or older were used in 16 of 147 PTx procedures (11%). The final decision to accept a graft for PTx was b...

journal_title：Transplantation proceedings

authors： Boggi U,Del Chiaro M,Signori S,Vistoli F,Amorese G,Croce C,Morelli L,Vanadia Bartolo T,Pietrabissa A,Barsotti M,Rizzo G,Mosca F

更新日期：2005-03-01 00:00:00

abstract：:Renal recipients with hepatitis B virus (HBV) should be treated with prolonged lamivudine. However, lamivudine resistance usually results after YMDD mutation within the HBV polymerase gene. Thereupon, the aim of this study was to investigate the genotypic resistance to lamivudine among renal transplant recipients to i...

journal_title：Transplantation proceedings

authors： Joh JW,Lee HH,Park JW,Lee DH,Yoo BC,Lee KW,Kim SJ

更新日期：2005-03-01 00:00:00